Research Progress on Regulatory Effects and Mechanism of <i>Akkermansia muciniphila</i> on Glycolipid Metabolism and Intestinal Health

XI Yijia; PAN Haiyu; WU Zhenglin; XU Guihu; LI Xiaoyin; GAO Yanhua

doi:10.13386/j.issn1002-0306.2024060336

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XI Yijia, PAN Haiyu, WU Zhenglin, et al. Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health[J]. Science and Technology of Food Industry, 2025, 46(8): 1−10. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024060336.

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Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health

Key Laboratory of Animal Science School of National Ethnic Affairs Commission of China, Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resources Reservation and Utilization, College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China

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Received Date: June 23, 2024
Available Online: February 12, 2025

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Abstract

Abstract

Akkermansia muciniphila (A. muciniphila) is a functional gut commensal bacterium. The imbalance in the distribution and abundance of A. muciniphila in the gastrointestinal tract is closely related to the occurrence of various diseases, including glucolipid metabolic disorders and enteritis. This review aims to provide a concise overview of the probiotic function of A. muciniphila in regulating glucose and lipid metabolism, alleviating intestinal inflammation, and enhancing intestinal barrier function, as well as its molecular mechanism of action. Meanwhile, to tackle the challenges of industrial applying A. muciniphila, such as defining a safe and effective supplemental dosage and creating a cost-efficient, high-density production process, new research directions are proposed to guide the development of A. muciniphila as a novel probiotic additive.
- Akkermansia muciniphila,
- probiotics,
- glucolipid metabolic disorders,
- intestinal health,
- molecular mechanism of action

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Science and Technology of Food Industry

Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health

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