Preparation and stability of the inclusion complex of HP-β- CD with morin

The water- soluble inclusion complex of morin and( 2- hydroxy) propyl-β- cyclodextrin( HP-β- CD) was prepared by freeze- drying method. The effects of the inclusion behavior of host- guest was investigated by methods of phase- solubility and characterized byscanning electron microscopy( SEM) and X- ray diffraction( XRD).Furthermore,the stability of morin and it inclusion complex was also investigated by differential scanning calorimetry( DSC),andphotostability test.The experiment showed thatmorin formed 1 ∶ 1 stoichiometric inclusion complex with HP- β- CD,and the apparent stability constant was 833( mol / L)- 1.The solubility of the morin was dramaticallyincreasedas it enhanced more than 9 times.Also the decomposition temperature of morin was improved from 294 ℃ to 341 ℃ after encapsulated by HP-β- CD and the photostability of morin was enhanced from 75.2% to82.7%.Therefore,it could be a potentially promising way to promote its stability as food additive in storage and application.