Effects of Dictyophora rubrovalvata polysaccharide on anti- aging and hypoglycemic in mice

Objective: To study anti- aging and hypoglycemic effects of Dictyophora rubrovalvata polysaccharide( DRP) in mice. Methods: DRP was extracted by using the method of water extraction and subsequent alcohol precipitation.The aging model was induced by subcutaneous injection of D- galactose,meanwhile,the mice were given different dose of DRP( 100 mg / kg·d,300 mg / kg·d) by oral gavage.After 35 days,activity of SOD,GSH- PX and concentration of MDA in the serum and liver were determined. Hyperglycemic mice models were established by subcutaneous injection of alloxan.The mice were given different dose of DRP( 100 mg / kg·d,300 mg / kg·d) by oral gavage.Fasting blood glucose was determined once a week. The two tests included blank control group and model group.Results: The activity of SOD and GSH- PX in the serum and liver increased significantly,MDA content decreased significantly.DRP could reduce the fasting blood glucose level of hyperglycemic mice,but the effect was limited.Conclusion: DRP had anti- aging effects on aging model mice but no hypoglycemic effect in mice.