Study on the hypoglycemic effect of the compounds of seaweed dietary fiber on diabetic mice

To study the hypoglycemic effect of the compounds of seaweed dietary fiber, diabetic mice model was established by intravenous injection of alloxan (i.v.) . Model mice were divided randomly into 5 groups:high group, middle group, low dose group, model control group, positive control group. Blank control group was added additionally, which used orthoglycemic mice instead. Corresponding compounds were administrated intragastrically (i.g.) , positive control group was intragastrically administrated with metformin hydrochloride 200mg/kg, model control group and blank control group used physiological saline instead. 30 days later, fasting blood glucose (FBG) , oral glucose tolerance (OGTT) , total cholesterol (TC) , high density lipoprotein (HDL-C) , low density lipoprotein (LDL-C) and triglyceride (TG) were tested. Mice pancreas were gathered by the surgery method for pathology examination. Compared with model group, FBG was extraordinary significantly decreased (p <0.01) and the weight loss was significantly alleviated (p <0.05) by high or middle dose of compounds. OGTT was remarkably improved, HDL-C was remarkably elevated and TG was remarkably decreased by middle dose of compounds. HDL-C was extraordinary remarkably elevated, LDL-C and TG was extraordinary significantly decreased by high dose of compounds. Pathology examination revealed that the damage of β cells was effectively alleviated by high or middle dose of compounds. In conclusion, fasting blood glucose of diabetic mice could be decreased effectively and β- cell damage could be alleviated by the compounds of seaweed dietary fiber.