Antibacterial effect of hops and extending the application[J]. Science and Technology of Food Industry, 2012, (23): 428-432. DOI: 10.13386/j.issn1002-0306.2012.23.071
Citation: Antibacterial effect of hops and extending the application[J]. Science and Technology of Food Industry, 2012, (23): 428-432. DOI: 10.13386/j.issn1002-0306.2012.23.071

Antibacterial effect of hops and extending the application

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  • Received Date: September 16, 2012
  • The hops (Humulus lupulus) commonly used for bitterness and aromatic flavours to beer, is botanically placed in flowering-plant Cannabinaceae, which is a climbing perennial herb. Some components are well-known for their pharmacologically active, such as resins, polyphenols (mainly xanthohumol and isoxanthohumol) and the essential oil. In the beginning, the aim of added hops to beer is for antibacterial and extend the shelf life of the beer. Except for brewing, recent pharmacological effects of hops and others applications had been concerned. The antibacterial effects derive from hops and extending the application were reviewed in this paper in order to offer consults for further research and development.
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  • [1]
    谢宗万.全国中草药汇编 (上册) [M].北京:人民卫生出版社, 1996:770-771.
    [2]
    卜慕华.我国栽培作物来源探讨[J].中国农业科学, 1981 (4) :86-89.
    [3]
    Verzele M, Keukeleire D D.Chemistry and analysis of hop and beer bitters[M].Elsevier Science Publishers BV, 1991:1-3.
    [4]
    路德维希·纳尔蔡斯.啤酒厂麦汁制备工艺技术[M].孙明波译.北京:中国轻工出版社, 1991:85-90.
    [5]
    Benitez J L, Forster A, Keukeleire D.Hops and hop products, manual of good practice[M].EBC and Verlag Hans Carl, 1997, Chapter5:98-107.
    [6]
    Mizobuchi S, Sato Y.A new flavanone with antifungal antifungal activity isolated from hops[J].Agriculture Biology Chemistry, 1984, 48 (11) :2771-2775.
    [7]
    Suzuki K, Ljima K, Yamashita H.Isolation of a hop-sensitive variant of Lactobacillus lindneri and identification of genetic markers for beer spoilage ability of lactic acid bacteria[J].Applied and Environmental Microbiology, 2005, 71 (9) :5089-5097.
    [8]
    Sakamoto K, Konings W N.Beer spoilage bacteria and hop resistance[J].International Journal of Food Microbiology, 2003, 89 (2/3) :105-124.
    [9]
    Langezaal C R, Chandra A, Scheffer J J.Antimicrobial screening of essential oils and extracts of some Humulus lupulus L.cultivars[J].Pharm Weekbl Sci, 1992, 14 (6) :353-356.
    [10]
    Tagashira M, Uchiyama K, Yoshimura T, et al.Inhibition by hop bract polyphenols of cellular adherence and water-insoluble glucan synthesis of mutans Streptococci[J].Bioscience, Biotechnology and Biochemistry, 1997, 61 (2) :332-335.
    [11]
    Barnes J M, Dupont T R, Barnes M E, et al.Initial investigations of hops as a salmonid egg fungicide[J].North American Journal of Aquaculture, 2012, 14 (3) :310-313.
    [12]
    Bhattacharya S, Virani S, Zavro M, et al.Inhibition of streptococcus mutans and other oral streptococci by hop (Humulus lupulus L.) constituents[J].Economic Botany, 2003, 57 (1) :118-125.
    [13]
    Shapouri R, Rahnema M.Evaluation of antimicrobial effect of hops extracts on in abortus and B.melitensis[J].Jundishapur Journal of Microbiol, 2011, 4 (2) :51-58.
    [14]
    Natarajana P, Kattab S, Andreic I, et al.Positive antibacterial coaction between hop (Humulus lupulus) constituents and selected antibiotics[J].Phytomedicine, 2008, 15 (3) :194-201.
    [15]
    Wilson R J H, Smith R J, Haas G.Application for hop acids as anti-microbial agents[P].US7910140B2, 2011.
    [16]
    Maye J P.Method for inhibiting bacteria growth during ethanol fermentation[P].US13/046362, 2011.
    [17]
    Mudura E, Rotar A, Paucean A, et al.Antimicrobial effect of hop dosage in beer[J].Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca.Agriculture, 2011, 68 (2) :543.
    [18]
    刘玉梅.啤酒花的分析评价及六氢蛇麻酮类的合成与应用[D].无锡:江南大学, 2007:80-82.
    [19]
    李时珍.本草纲目[M].北京:人民卫生出版社, 1972.
    [20]
    叶桔泉.食物中药与便方[M].江苏:江苏科学出版社, 1971.
    [21]
    Kuhrts E.New COX-2inhibitory composition comprising extract of hops containing anα-acid-useful for reducing inflammation and minimizing gastric erosion[P].WO2004062611-A2, 2004-07-29.
    [22]
    Yasukawa K, Takeuchi M, Takido M.Humulone, a bitter in the hop, inhibits tumor promotion by12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin[J].Oncology, 1995, 52 (2) :156-158.
    [23]
    Buckwold V E, Wilson R J, Nalca A, et al.Antiviral activity of hop constituents against a series of DNA and RNA viruses[J].Antiviral Res, 2004, 61 (1) :57-62.
    [24]
    Shimura M, Hasumi A, Minato T.Isohumulones modulate blood lipid status through the activation of PPAR-alpha[J].Biochimica et Biophysica Acta, 2005, 1736 (1) :51-60.
    [25]
    Chen W J, Lin J K.Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by fas and caspase cascades[J].Journal of Agricultural and Food Chemistry, 2004, 52 (1) :55-64.
    [26]
    Bravo L, Cabo J, Fraile A, et al.Pharmacodynamic Study of the Lupulus’ (Humulus lupulus L.) Tranquilizing Action[J].Boll Chim Farm, 1974, 13 (5) :310-315.
    [27]
    Anto R J, Sukumaran K, Kuttan G, et al.Anticancer and antioxidant activity of synthetic chalcones and related compounds[J].Cancer Letters, 1995, 97 (1) :33-37.
    [28]
    Pharmar V S, Bracke M E, Philippe J, et al.Anti-invasive activity of alkaloids and polyphenolic in vitro[J].Bioorganic Medicine and Chemistry, 1997, 5 (8) :1609-1619.
    [29]
    Henderson M C, Miranda C L, Stevens J F, et al.In vitro inhibition of human P450enzymes by prenylated flavonoids from hops, Humulus lupulus[J].Xenobiotica, 2000, 30 (3) :235-251.
    [30]
    Miranda C L, Aponso L, Stevens J F, et al.Prenylated chalcones and flavanones as inducers of quinone reductase in mouse hepatoma (Hepa lclc7) cells[J].Cancer Letters, 2000, 149 (1/2) :21-39.
    [31]
    Lust S, Vanhoecke B, Janssens A, et al.Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism[J].Molecular Nutrition&Food Research, 2005, 49 (9) :844-850.
    [32]
    Honma Y, Tobe H, Makishima M, et al.Induction of differentiation of myelogenous leukemia cells by humulone, a bitter in the hop[J].Leukemia Res, 1998, 22 (7) :605-610.
    [33]
    Saugspier M, Dorn C, Thasler W E, et al.Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro[J], Experimental and Molecular Pathology, 2012, 92 (2) :222-228.
    [34]
    刘莎, 刘玉梅.啤酒花多酚提取物的抗氧化活性研究[J].酿酒科技, 2010 (10) :19-22.
    [35]
    刘莎, 姜春耕, 刘玉梅.啤酒花多酚超声提取工艺及清除O-2·的活性研究[J].中国酿造, 2010 (11) :59-62.
    [36]
    赵素华, 司琴图亚.黑加仑、榅桲、无花果、桑椹和啤酒花苦味酸及制品抗氧化作用研究[J].食品科学, 2002, 23 (2) :35-37.
    [37]
    Gerhauser C.Broad spectrum antiinfective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites[J].Molecular Nutrition&Food Research, 2005, 49 (9) :827-831.
    [38]
    Stevens J F, Ivancic M, Hsu V L, et al.Prenylflavonoids from humulus lupulus[J].Phytochemistry, 1997, 44 (8) :1575-1585.
    [39]
    Miranda C L, Stevens J F, Helmrich A, et al.Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines[J].Food and Chemical Toxicology, 1999, 37 (4) :271-285.
    [40]
    汪江碧, 罗蓉, 田雪松, 等.啤酒花对去卵巢肥胖大鼠的影晌[J].中药材, 2004, 27 (2) :1105-107.
    [41]
    Miligan S R, Kalita J C, Pocock V, et al.The endocrine actitives of8-prenyl naringenin andrelated hopnavonoids[J].Journal of Clin Endocrinol Metab, 2000, 85 (12) :4912.
    [42]
    应雀森, 潘勤, 张娟.啤酒花的化学成分、药理作用与临床应用[J].国外医药:植物药分册, 2008, 23 (4) :139-142.
    [43]
    Bourges S.Hop extracts and their use in preparation of a medicament having oestrogenic properties, patent:FR2823672A1.
    [44]
    Kondo K.Beer and health:Preventive effects of beer components on lifestyle-related diseases[J].BioFactors, 2004, 22:303-310.
    [45]
    Yajima H, Ikeshima E, Shiraki M, et al.Bitter acids derived from hops, activate both peroxisome proliferator-activated receptorαandγand reduce insulin resistance[J].Journal of Biological Chemistry, 2004, 279 (32) :33456-33462.
    [46]
    Shindo S, Tomatsu M, Nakda T, et al.Inhibition of aldose reductase activity by extracts from hops[J].Journal of the Institute of Brewing, 2002, 108 (3) :344-347.
    [47]
    张肇富.啤酒花具有药用价值[J].酿酒科技, 2000 (1) :94.
    [48]
    宋振玉.中草药现代研究[M].北京:北京医科大学出版社, 1997.
    [49]
    Anton P.The physiological effects of hops[J].Hopfenrund Schau International, 2001/2002:1-2.
    [50]
    苏德利.啤酒花在兽医临床上的应用[J].吉林畜牧兽医, 1994, 16 (6) :31-32.
    [51]
    Green M R, Richards M, Tasker M C.Use of hop components in foods[P].WO03/090555A1.
    [52]
    董海州, 许志祥, 刘传富.改善馒头风味品质的最佳生产工艺[J].食品与发酵工业, 2003, 29 (4) :95-98.
    [53]
    Hein W, Pollach G, Roesner G.Studies of microbiological activities during thick juice storage[J].Zuckerindustrie, 2002, 127 (4) :243-257.
    [54]
    Hein W, Pollach G.New findings with the use of hop products in the sugar industry[J].Zuckerindustrie, 1997, 122 (12) :940-949.
    [55]
    Pollach G, Hein W, Leitner A, et al.Detection and control of strictly anaerobic, spore-forming bacteria in sugarbeet tower extractors[J].Zuckerindustrie, 2002, 127 (7) :530-537.
    [56]
    Pollach G, Hein W, Beddie D.Application of hop beta-acids and rosin acids in the sugar industry[J].Zuckerindustrie, 2002, 127 (12) :921-930.
    [57]
    Beddie D, Isles N, Wirth T, et al.Successful application points to control bacterial infections throughout sugar factories using beta acids/betaStab10A[C].Poster-Presentation on the Occasion of the SPRI Conference in Atlanta Georgia USA, 2004:4-7.
    [58]
    Rückle L, Senn T.Hop acids can efficiently replace antibiotics in ethanol production[J].International Sugar Journal, 2006, 108 (1287) :139-147.

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