Optimization of extraction process of polyphenols from Choerospondias axillaris peel by response surface methodology

Response surface methodology was employed to optimize the extraction of polyphenols from Choerospondias axillaris peel residue based on one-factor-at-a-time experiments.The influences of ethanol concentration, extraction time, extraction temperature and solid-to-liquid ratio on the extraction of polyphenols were studied.A regression model for total polyphenols yield as a function of four factors was built.Results indicated that extraction at 59℃ for 52min with a 30-fold volume of 52% ethanol aqueous solution yielded the most total polyphenols, reaching 51.916mg/g, which was basically in accordance with the model-predicted value.In conclusion, the optimized extraction process is reliable and can be used for the development of products based on Choerospondias axillaris peel polyphenols.