Abstract: Quantitative analysis of multi-components by single marker (QAMS) is a new method of multi-component quality evaluation, which has been successfully applied in the multi-component detection of food, especially to solve the problem of shortage of reference materials and high detection cost in multi-component quantitative analysis. This paper mainly reviews all the research progress of using QAMS technology in food detection since 2012.At the same time, it discusses and looks forward to some key problems in the application of QAMS, including the location of chromatographic peaks, detection of low UV absorption compounds, and detection of different types compounds, with a view to continuous research and improvement, and more and more widely used in food research and production practice.