摘要:
目的:探讨苏氨酸铁(Thr-Fe)对缺铁性贫血(IDA)大鼠铁营养状况的改善作用。方法:以低铁饲料饲喂雄性初断乳斯泼累格·多雷(SD)大鼠建立IDA模型,设置3个不同Thr-Fe剂量组和阳性对照组、低铁对照组、空白对照组,每组6只,每天灌胃1次,连续给药21 d,Thr-Fe剂量组分别给予8、16、32 mg/kg·bw的Thr-Fe,阳性对照组给予32 mg/kg·bw硫酸亚铁。结果:较低铁对照组,Thr-Fe高剂量组大鼠体重及血红蛋白、血清铁蛋白等血液指标显著提高(p<0.01),血清转铁蛋白(p<0.01)和总铁结合力(p<0.05)显著降低,各Thr-Fe剂量组大鼠游离原卟啉显著降低(p<0.01)。Thr-Fe高剂量组IDA大鼠各项指标改善优于阳性对照组。结论:低铁膳食补充Thr-Fe可以改善IDA大鼠的铁营养状况,提高功能铁及贮存铁含量,促进机体铁转运。Thr-Fe对IDA大鼠体重及血红蛋白等的影响呈剂量相关性,Thr-Fe对IDA大鼠铁营养状况的改善效果优于硫酸亚铁。
Abstract:
Objective:The effects of ferrous threonine chelate(Thr-Fe)on improving the iron status of rats suffering iron deficiency anemia(IDA)were investigated. Method:The IDA model of male weaning SD rats was established by iron-deficiency diet. And IDA rats were randomly divided into three Thr-Fe dose groups,positive control group,low-Fe control group,basing on their hemoglobin contents and body weights. A blank control group was set up,in addition. There were 6 rats in each group. The 8,16,32 mg/kg·bw of Thr-Fe were orally administered to the three Thr-Fe dose groups once a day,respectively,lasting 21 days uninterruptedly;32 mg/kg·bw of ferrous sulfate was given to positive control group in the same way. Results:After recovery test,the blood indexes such as hemoglobin and serum ferritin of IDA rats and the body weights in Thr-Fe high dose groups were improved and significantly higher(p<0.01)than those in low-Fe control group,while the transferrin(p<0.01)and total iron binding capacity(p<0.05)were significantly lower,and the free erythrocyte protephyrin of the three Thr-Fe dose groups were significantly lower(p<0.01). The indexes of IDA rats in high dose group of Thr-Fe were better than that in positive control group. Conclusion:Supplements of Thr-Fe could improve the iron status of IDA rats,increasing the contents of functional iron and iron storage,promoting iron transportation. Effects of Thr-Fe on body weights and hemoglobin of IDA rats are dose-dependent and the effects of Thr-Fe on iron status of IDA rats are better than that of ferrous sulfate.
下载:
