A comparative study on the hypolipidemic activities of various solvent extracts derived from Ilex kudingcha C.J.Tseng
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摘要: 本文通过高脂饲料诱导建立大鼠高血脂模型,比较研究苦丁茶冬青中石油醚、乙酸乙酯、正丁醇和水4种萃取组分的降血脂活性。结果显示,苦丁茶冬青石油醚萃取物得率为1.83%,乙酸乙酯萃取物得率为1.65%,正丁醇萃取物得率为6.49%,水提物得率为6.97%。苦丁茶冬青不同萃取组分对高脂诱导高血脂大鼠体重增加、血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）升高均具有改善作用,其中石油醚萃取物能显著抑制高血脂大鼠体重增加和显著降低高血脂模型大鼠血清中TC和TG含量（p<0.05）。结果表明苦丁茶冬青不同萃取物组分均具有一定调节血脂和调节高胆固醇血症的功效,本文可为苦丁茶冬青降血脂和调节胆固醇保健品的开发提供理论依据。Abstract: Extracts were prepared from Ilex kudingcha C.J.Tseng by 80% ethanol, and followed by liquid-liquid extraction with petroleum ether, ethyl acetate, n-butanol, and water, respectively. The hypolipidemic activities of the four extracts were investigated with a model of hyperlipidemia in rats.Results showed that the yields of these four solvent extracts were of 1.83%, 1.65%, 6.49%, and 6.97%, respectively. The hypolipidemic results showed that the four solvent extracts could ameliorate the symptoms of hyperlipidemia to some extent, including decreased the body weight gaining, and decreased the serum levels of TC, TG and LDL-C.Especially, the petroleum ether component significantly ( p < 0.05) decreased body weight and the serum levels of TC, TG and LDL-C in high fat diet-induced hyperlipidemia rats.These results suggested that bioactive extracts derived from Ilex kudingcha C.J. Tseng might had an important role in modulating hyperlipidemia and provided theoretical evidences for exploiting healthy food of Ilex kudingcha C.J.Tseng.
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