Research progress in composition structure and functional activity of Theabrownin
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摘要: 茶褐素是由茶黄素和茶红素进一步氧化聚合而成的褐色高聚物,其结构中含有羟基、羧基、烷基和苯环类似物等,具较强的抗氧化、抗癌、降血脂等功效。本文综述了茶褐素的组成结构、形成与积累和功能活性;最后,提出茶褐素在当前研究中面临的困境,并进行了展望。Abstract: Theabrownin is a brown polymer which is formed by the further oxidation and polymerization of theaflavin and thearubigins; in terms of its structure, it contains hydroxyl, carboxyl, alkyl and benzene analogs, so it is endowed with relatively strong antioxidant, anticancer, reducing blood lipid and other efficacy. This paper summarizes the composition structure, formation and accumulation, and functional activity.Finally, puts forward the difficulties confronted in the current research and envisions its prospect.
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Keywords:
- Theabrownin /
- composition structure /
- functional activity
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[1] Wang Q, Peng C, Gong J.Effects of enzymatic action on the formation of theabrownin during solid state fermentation of Pu-er tea[J].Journal of the Science of Food&Agriculture, 2011, 91 (13) :2412-2418.
[2] 陈应娟, 齐桂年, 陈盛相, 等.四川黑茶加工过程中感官品质和化学成分的变化[J].食品科学, 2012 (23) :55-59. [3] 龚加顺, 陈文品, 周红杰, 等.云南普洱茶特征成分的功能与毒理学评价[J].茶叶科学, 2007, 27 (3) :201-210. [4] Peng C X, Liu J, Liu H R, et al.Influence of different fermentation raw materials on pyrolyzates of Pu-er tea theabrownin by Curie-point pyrolysis-gas chromatography-mass spectroscopy[J].International Journal of Biological Macromolecules, 2013, 54 (1) :197-203.
[5] 王伟伟, 江和源, 张建勇, 等.茶褐素的提取纯化与生理功效研究进展[J].食品安全质量检测学报, 2015 (4) :1187-1192. [6] Huang Q, Chen S, Chen H, et al.Studies on the bioactivity of aqueous extract of pu-er tea and its fractions:In vitro antioxidant activity andα-glycosidase inhibitory property, and their effect on postprandial hyperglycemia in diabetic mice[J].Food&Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association, 2013, 53:75-83.
[7] Zhang H M, Wang C F, Shen S M, et al.Antioxidant phenolic compounds from Pu-er tea.[J].Molecules, 2012, 17 (12) :14037-14045.
[8] Braud L, Sousa G D, Peyre L, et al.0217:Antioxidant and protective effects of a Pu-er tea extract (camellia sinensis) on primary cultured rat cells[J].Archives of Cardiovascular Diseases Supplements, 2015, 7 (2) :141-143.
[9] Zhao X, Song J L, Kim J D, et al.Fermented Pu-er tea increases in vitro anticancer activities in HT-29 cells and has antiangiogenetic effects on Huvecs.[J].Journal of Environmental Pathology Toxicology&Oncology Official Organ of the International Society for Environmental Toxicology&Cancer, 2013, 32 (4) :275-288.
[10] Zhao X, Qian Y, Zhou Y L, et al.Pu-er tea has in vitro anticancer activity in TCA8113 cells and preventive effects on buccal mucosa cancer in U14 cells injected mice in vivo.[J].Nutrition&Cancer, 2014, 66 (6) :1-11.
[11] Zhao X, Song J, Park K Y.[P8-297]In vitro Anticancer Effect of Fermented Pu-er Tea in HT-29 Human Colon Cancer Cells[J]..
[12] Cao Z, Gu D, Lin Q Y, et al.Effect of Pu-er tea on body fat and lipid profiles in rats with diet-induced obesity[J].Phytotherapy Research, 2011, 25 (2) :234-238.
[13] Ding Y H, Zou X J, Jiang X, et al.Pu-er Tea DownRegulates Sterol Regulatory Element-Binding Protein and Stearyol-Co A Desaturase to Reduce Fat Storage in Caenorhaditis elegans[J].Plos One, 2015, 10 (2) :251-256.
[14] Cai X, Fang C, Hayashi S, et al.Pu-er tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice[J].Journal of Gastroenterology, 2016:1-11.
[15] Roberts E A H, Smith R F.The phenolic substances of manufactured tea.IX.—the spectrophotometric evaluation of tea liquors[J].Journal of the Science of Food&Agriculture, 1963, 14.
[16] Ponce E, Taylor A J.Phenolic Compounds as Astringent Factors in Black Tea Liquors[M].Springer US, 1999:197-209.
[17] 萧伟祥, 张丽平, 萧瑶珍.红茶汤中茶褐素的研究[J].茶叶, 1985, 12 (1) :53-55. [18] 秦谊, 龚加顺, 张惠芬, 等.Ba Cl2和Ca (CH3COO) 2沉淀法定量分析普洱茶茶褐素官能团[J].林产化学与工业, 2010, 30 (6) :107-112. [19] 杨大鹏.云南普洱茶茶褐素主要化学成分的分离及结构鉴定[D].云南农业大学, 2009. [20] 谭超, 彭春秀, 高斌, 等.普洱茶茶褐素类主要组分特征及光谱学性质研究[J].光谱学与光谱分析, 2012, 32 (4) :1051-1056. [21] 李连喜.不同制法普洱茶茶褐素及其在贮存中变化的研究[D].西南大学, 2005. [22] Zhang Q, Dong L X, Gai-Qing L I.Study on Membrane Separation and Its Physicochemical Properties of Theabrownin in‘Zijuan’Pu-er Tea[J].Journal of Tea Science, 2012, 3 (3) :34-36.
[23] Millin D J, Swaine D, Dix P L.Separation and classification of the brown pigments of aqueous infusions of black tea[J].Journal of the Science of Food&Agriculture, 1969, 20 (5) :296-302.
[24] 赵楠, 高慧媛, 孙博航, 等.茶叶的化学成分[J].瀋陽藥科大學學報, 2007, 24 (4) :211-214. [25] Vuataz L, Brandenberger H.Plant phenols:III.Separation of fermented and black tea polyphenols by cellulose column chromatography[J].Journal of Chromatography A, 1961, 5 (1) :17-31.
[26] 吕虎, 孔庆友.茶色素制取及其化学组成[J].林产化学与工业, 2000, 20 (4) :63-68. [27] 杨大鹏.云南普洱茶茶褐素主要化学成分的分离及结构鉴定[D].云南农业大学, 2009. [28] 董文明, 谭超, 龚加顺.普洱茶茶褐素中2种水溶性成分研究[J].食品科学, 2013, 34 (23) :32-35. [29] 杨贤强.茶多酚化学[M].上海科学技术出版社, 2003. [30] 竹尾忠一, 刘仲华.乌龙茶和红茶香气的食品化学研究[J].茶叶科学技术, 1986 (2) :40-42. [31] 张钦, 张峰, 龚加顺.红茶茶褐素化学组成及理化性质的分析[J].食品科技, 2012 (6) :281-284. [32] 崔文锐.红茶贮藏中温度对茶色素的影响初探[J].福建茶叶, 2005 (2) :6-8. [33] 何青元.云南普洱茶加工工艺探讨[J].贵州茶叶, 2002 (3) :13-15. [34] 闫列娟.陕南黑茶加工工艺研究[D].西北农林科技大学, 2012. [35] 刘婷婷, 齐桂年, 邹瑶, 等.四川黑茶渥堆过程中主要品质成分及酶类活性变化[J].华南农业大学学报, 2015, 36 (4) :112-116. [36] 李伟, 齐桂年, 邹瑶, 等.四川黑茶渥堆过程中感官品质的变化及影响因子研究[J].华南农业大学学报, 2015, 36 (5) :125-129. [37] 周红杰, 李家华, 甘月明, 等.普洱茶渥堆过程化学成分变化与品质形成的关系[J].茶苑, 2004 (1) :6-8. [38] 杨大鹏, 史文斌, 陈一江, 等.不同微生物发酵的云南普洱茶样中茶褐素提取物的化学成分分析[J].林产化学与工业, 2010, 30 (1) :49-52. [39] Chun-Xiu P, Jian L, Hua-Rong L, et al.Influence of different fermentation raw materials on pyrolyzates of Pu-er tea theabrownin by Curie-point pyrolysis-gas chromatography-mass spectroscopy.[J].International Journal of Biological Macromolecules, 2012, 24 (8) :104-107.
[40] Qiuping W, Chunxiu P, Jiashun G.Effects of enzymatic action on the formation of theabrownin during solid state fermentation of Pu-er tea.[J].Journal of the Science of Food and Agriculture, 2011, 91 (13) :234-237.
[41] 陈保, 刘新月, 蒲泓君, 等.不同普洱茶原料渥堆发酵过程中主要化学成分的变化研究[J].食品安全质量检测学报, 2015 (4) :1279-1286. [42] 胡捷.不同季节普洱茶渥堆过程动态分析[D].华南理工大学, 2013. [43] 董文明, 谭超, 李凌飞, 等.普洱茶发酵过程中茶褐素主要分子结构及其变化研究[J].食品科技, 2013 (4) :53-57. [44] 黄秋桂, 张灵枝, 谭新东.黑茶发酵优势菌对茶多酚的生物转化研究[J].广东农业科学, 2014, 41 (19) :86-89. [45] 谭超, 龚加顺, 保丽萍.“紫娟”绿茶发酵过程中茶褐素理化性质及微生物变化[J].食品与发酵工业, 2011, 37 (12) :43-48. [46] 刘通讯, 谭梦珠.不同干燥温度对普洱茶多酚类物质和香气成分的影响[J].现代食品科技, 2015 (4) :264-271. [47] 徐瑞雪, 杜丽平, 郝瑞雪, 等.普洱茶液态自然发酵的工艺研究[J].食品工业科技, 2012 (11) :243-246. [48] 韦柳花, 苏敏, 陈三弟, 等.不同贮存时间六堡茶品质变化研究[J].西南农业学报, 2015 (1) :376-380. [49] 沈丽萍, 刘春丽, 刘智敏.贮藏条件对普洱茶品质成分的影响研究[J].生物技术世界, 2015 (4) :156-157. [50] Qasim M, Aziz I, Rasheed M, et al.Effect of extraction solvents on polyphenols and antioxidant actixity of medicinal halophytes[J].Pakistan Journal of Botany, 2016, 48 (2) :621-627.
[51] Kumar P, Yadav D, Kumar P, et al.Comparative study on conventional, ultrasonication and microwave assisted extraction ofγ-oryzanol from rice bran[J].Journal of Food Science and Technology, 2016, 8 (2) :1-7.
[52] Pal S, Ghosh D, Saha C, et al.Total polyphenol content, antioxidant activity and lipid peroxidation inhibition efficacy of branded tea (Camellia sinensis) available in India[J].International Journal of Tea Science, 2016, 18 (9) :13-20.
[53] Chedea V, Pelmus R S, Cismileanu A E, et al.Total polyphenols content, antioxidant activity and stability of a grape pomace incorporated in animal feed[J].Scientific Papers Animal Science&Biotechnologies, 2016, 20 (12) :1157-1160.
[54] Fanali C, Belluomo M G, Cirilli M, et al.Antioxidant activity evaluation and HPLC-photodiode array/MS polyphenols analysis of Pomegranate Juice from selected italian cultivars:Acomparative study[J].Electrophoresis, 2016, 16 (9) :157-160.
[55] Zhao L I, Hongqiang L I, Guogang C, et al.Effects of extraction agents on the antioxidant activity and condensability of polyphenol[J].Journal of Shandong University, 2016, 26 (14) :1057-1060.
[56] 何英姿, 逯钊琦, 陈艳芳, 等.六堡茶茶褐素的提取工艺及其抗氧化活性研究[J].安徽农业科学, 2012, 40 (35) :17301-17303. [57] 陈梅春, 张海风, 潘志针, 等.陈年普洱茶香气成分及清除DPPH自由基活性研究[J].中国农学通报, 2015, 14 (4) :274-29. [58] 刘通讯, 谭梦珠.不同储存时间对普洱茶有机溶剂萃取物清除自由基活性的影响[J].现代食品科技, 2013 (10) :2372-2377. [59] 周向军, 高义霞, 袁毅君, 等.乌龙茶茶褐素提取工艺的优化及抗氧化研究[J].中国实验方剂学杂志, 2011 (4) :36-40. [60] 董文明, 谭超, 龚加顺.影响普洱茶茶褐素清除DPPH自由基效果的因素 (英文) [J].Agricultural Science&Technology, 2013, 14 (2) :317-323. [61] 易恋.普洱茶多酚与茶褐素的分离及功能研究[D].湖南农业大学, 2010. [62] Peng C X, Wang Q P, Liu H R, et al.Effects of Zijuan Pu-er tea theabrownin on metabolites in hyperlipidemic rat feces by PyGC/MS[J].Journal of Analytical&Applied Pyrolysis, 2013, 104 (10) :226-233.
[63] Gong J, Peng C, Chen T, et al.Effects of Theabrownin from Pu-er Tea on the Metabolism of Serum Lipids in Rats:Mechanism of Action[J].Journal of Food Science, 2010, 75 (6) :182-189.
[64] 陈智雄, 齐桂年, 迟琳.黑茶茶褐素类物质的提取及对脂肪酸合酶的抑制研究进展[J].福建茶叶, 2012 (2) :10-14. [65] Liu J, Peng C X, Gao B, et al.Serum metabolomics analysis of rat after intragastric infusion of Pu-er theabrownin[J].J.Sci.Food Agric, 2016, 96 (11) .
[66] Jinlin Bian, Jinlong Guo, Pinwu L.I., 等.雅安藏茶对脂肪酶的抑制作用[J].食品科学, 2015, 36 (3) :23-28. [67] 边金霖, 郭金龙, 李品武, 等.雅安藏茶对胃蛋白酶的促进作用[J].四川农业大学学报, 2015, 25 (3) :279-284. [68] 郝文幸, 王淼, 吕梦娴.宜兴红茶茶色素对α-葡萄糖苷酶抑制作用的研究[J].中国科技论文在线, 2015, 26 (5) :33-38. [69] 徐湘婷, 王鹏, 罗绍忠, 等.普洱熟茶茶褐素对Ⅱ型糖尿病小鼠降糖作用研究[J].中国民族民间医药, 2015 (20) :9-10. [70] 贺国文, 钟桐生, 彭晓赟, 等.茯砖茶褐素组分特征及对α-葡萄糖苷酶活性抑制研究[J].茶叶科学, 2016 (1) :102-110. [71] Xiangting X U, Wang P, Luo S, et al.Hypoglycemic Effects of Fermented Puer tea Extracts-Theabrownins in Mice of Type 2Diabetes[J].Chinese Journal of Ethnomedicine&Ethnopharmacy, 2015, 20 (26) :117-119.
[72] 沈丽萍, 光映霞.茶黄素的制备及功能活性研究进展[J].北京农业, 2015, 7 (14) :213-216. [73] 卢素芳, 王胜鹏.茶色素及其生物活性功能研究[J].湖北农业科学, 2015, 17 (24) :6117-6119. [74] Shimamura Y, Aoki N, Sugiyama Y, et al.Screening of Tea Extract and Theaflavins for Inhibitory Effects on the Biological Activity and Production of Staphylococcal Enterotoxin A[J].Journal of Food Science, 2014, 79 (11) :2294-2300.
[75] 杨新河, 王丽丽, 黄建安, 等.普洱茶茶褐素的分级及相关性质初步研究[J].茶叶科学, 2011, 31 (3) :187-194. [76] 赵欣, 王强.普洱茶粗提物的体外抗癌及体内抗肿瘤转移效果研究[J].营养学报, 2013, 35 (6) :563-566. [77] 岳随娟, 刘建, 龚加顺.普洱茶茶褐素对大鼠肠道菌群的影响[J].茶叶科学, 2016 (3) :261-267. [78] 聂坤伦, 何利, 速晓娟, 等.雅安藏茶抑制α-淀粉酶的活性级分筛选与评价[J].食品科学, 2013, 34 (9) :74-79. [79] 边金霖, 郭金龙, 李品武, 等.雅安藏茶对脂肪酶的抑制作用[J].食品科学, 2015, 36 (3) :23-28. [80] 边金霖, 郭金龙, 李品武, 等.雅安藏茶对胃蛋白酶的促进作用[J].四川农业大学学报, 2015 (3) :279-284. [81] 龚加顺, 陈文品, 周红杰, 等.云南普洱茶特征成分的功能与毒理学评价[J].茶叶科学, 2007, 27 (3) :201-210.
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