Research progress in the anti- tumor activities and related mechanisms of plant polyphenols
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摘要: 癌症是世界第二常见疾病,发病率逐年增加。尽管各种针对性的治疗手段快速发展,但癌症死亡率仍保持在一个惊人的水平。因此,攻克癌症需要寻求更有效的手段。现代研究表明,植物多酚在预防和治疗癌症方面都表现出了良好的生物学活性。本文就近年来国内外对植物多酚的抗肿瘤活性和机制研究进展进行综述,以期为植物多酚的充分利用提供参考。Abstract: Cancer is the second most common disease in the world,and its incidence is increasing annually.Despite of the rapid development of various targeted therapeutic approaches,mortality related to cancer remains at a staggering high level. Therefore,more effective therapeutic strategies are required to combat cancer. Modern researches showed that plant polyphenols had shown good biological activities in the prevention and treatment of cancer.In order to provide reference for making full use of the resource of plant polyphenols,the research progress in the anti- tumor activities and related mechanisms of plant polyphenols were summarized in this paper in recent years.
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Keywords:
- plant polyphenols /
- anti-tumor activity /
- mechanism research
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[1] Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386.
[2] 杨吉龙.调查揭示中国癌症生存率远低于发达国家[J].中国肿瘤临床,2014,41(24):1607-1608. [3] Liu J R,Dong H W,Chen B Q,et al.Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat[J].J Agr Food Chem,2009,57(1):297-304.
[4] Zhang Q,Cui C,Chen C Q,et al.Antiproliferative and proapoptotic activities of Alpinia oxyphylla on Hep G2 cells through ROS-mediated signaling pathway[J].J Ethnopharmacol,2015,169(1):99-108.
[5] Ouyang L,Luo Y,Tian M,et al.Plant natural products:from traditional compounds to new emerging drugs in cancer therapy[J].Cell Proliferat,2014,47(6):506-515.
[6] Varoni E,Lodi G,Sardella A,et al.Plant Polyphenols and Oral Health:Old Phytochemicals for New Fields[J].Curr Med Chem,2012,19(11):1706-1720.
[7] Korkina L,Luca C D,Pastore S.Plant polyphenols and human skin:friends or foes[J].Ann NY Acad Sci,2012,1259(11):77-86.
[8] María D G,Rocasalbas G,Francesko A,et al.Inhibition of deleterious chronic wound enzymes with plant polyphenols[J].Biocatal Biotransfo,2012,30(1):102-110.
[9] Lin Y,Xia X,Yao R,et al.Synthesis and in vitro biological evaluation of hybrids from tetrahydro-betacarboline and hydroxycinnamic acid as antitumor carcinoma agents[J].Chem Phram Bull(Tokyo),2014,62(4):343-349.
[10] Pontiki E,Hadjipaviou-Litina D,Litinas K,et al.Novel cinnamic acid derivatives and anticancer agents:design,synthesis and modeling studies[J].Molecules,2014,19(7):9655-9674.
[11] Peng Z G,Yao Y B,Yang J,et al.Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leu-kemia cells[J].Genet Mol Res,2015,14(2):4989-5002.
[12] Chaabane F,Pinon A,Simon A,et al.Chloroform leaf extract of Daphne gnidium inhibits growth of melanoma cells and enhances melanogenesis of B16-F0 melanoma[J].S Afr J Bot,2014,90:80-86.
[13] Lee E J,Moon G S,Choi W S,et al.Naringin-induced p21WAF1-mediated G1-phase cell cycle arrest via activation ofthe Ras/Raf/ERK signaling pathway in vascular smooth muscle cells[J].Food Chem Toxicol,2008,46(12):3800-3876.
[14] Schoene N W,Kelly M A,Polansky M A,et al.Watersoluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines[J].Cancer Lett,2005,230(1):134-140.
[15] Lau F Y,Chui C H,Gambari R,et al.Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells[J].Int J Mol Med,2005,16(6):1157-1162.
[16] Park H K,Han D W,Park Y H,et al.Differential biological responses of green tea polyphenol in normal cells vs.cancer cells[J].Curr Appl Phys,2005,5(5):449-452.
[17] Liu W,Guo Q L,You Q D,et al.Anticancer effect and apoptosis induction of gambogic acid in human gast ric cancer line BGC2823[J].World J Gastroenterol,2005,11(24):3655-3659.
[18] 黄雨洋.红松多酚分离鉴定及抗氧化抗癌功能研究[D].哈尔滨:东北林业大学,2014. [19] 左丽丽.狗枣猕猴桃多酚的抗氧化与抗肿瘤效应研究[D].哈尔滨:哈尔滨工业大学,2013. [20] Lee T K,Johnke R M,Allison R R,et al.Radioprotective potential of ginseng[J].Mutagenesis,2005,20(4):237-243.
[21] Joshua D,Ryan J.The antioxidant and pro-oxidant activities of green tea polyphenols:A role in cancer prevention[J].Arch Biochem Biophys,2010,1(501):65-72.
[22] Xie J,Xu Y Y,Huang X Y,et al.Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway[J].Tumor Biol,2015,36(2):1279-1288.
[23] Cromie M M,Gao W.Epigallocatechin-3-Gallate Enhances the Therapeutic Effects of Leptomycin B on Human Lung Cancer A549 Cells[J].Constr Approx,2015,2015(2):1-10.
[24] Yi J J,Wang Z Y,Bai H N,et al.Polyphenols from pinecones of Pinus koraiensis induce apoptosis in colon cancer cells through the activation of caspase in vitro[J].RSC Adv,2016,6(7):5278-5287.
[25] Serra A T,Matias A A,Frade R F M,et al.Characterization of traditional and exotic apple varieties from Portugal.Part2-Antioxidant and antiproliferative activities[J].J Funct Foods,2010,2(1):46-53.
[26] Berdowska I,Zielinski B,Fecka I,et al.Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells[J].Food Chem,2013,141(2):1313-1321.
[27] Sagara Y,Miyata Y,Nomata K,et al.Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl)nitrosamine-induced bladder cancer.[J].Cancer Epidemiol,2010,34(34):350-354.Sagara Y,Miyata S,Nomata K,et al.Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl)nitrosamine-induced bladder cancer[J].Oxidative Stress and Dietary Antioxidants,2010,34(3):350-354.
[28] Hajiaghaalipour F,Kanthimathi M S,Sanusi J,et al.White tea(Camellia sinensis)inhibits proliferation of the colon cancer cell line,HT-29,activates caspases and protects DNA of normal cells against oxidative damage[J].Food Chem,2015,169(15):401-410.
[29] 苏晓雨.红松种壳组成及多酚提取分离与抗氧化抗肿瘤功能研究[D].哈尔滨:哈尔滨工业大学,2010. [30] Darvin P,Joung Y H,Nipin S P,et al.Sorghum polyphenol suppresses the growth as well as metastasis of colon cancer xenografts through co-targeting jak2/STAT3 and PI3K/Akt/m TOR pathways[J].J Funct Foods,2015,15(5):193-206.
[31] Narayanan N K,Kunimasa K,Yamori Y,et al.Antitumor activity of melinjo(Gnetum gnemon L.)seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo[J].Cancer Med,2015,4(11):1767-1780.
[32] Yi J J,Wang Z Y,Bai H N,et al.Optimization of Purification,Identification and Evaluation of the in vitro antitumor activity of polyphenols from Pinus Koraiensis Pinecones[J].Molecules,2015,20(6):10450-10467.
[33] Lin X,Wu G,Huo W Q,et al.Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells[J].Int J Urol,2012,19(8):757-764.
[34] Li X,Huang J M,Wang J N,et al.Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by upregulating p53[J].Chem-Biol Interact,2015,232(5):12-20.
[35] Liang J,Li F,Fang Y,et al.Cytotoxicity and apoptotic effects of tea polyphenol-loaded chitosan nanoparticles on human hepatoma Hep G2 cells[J].Mat Sci Eng A-struct Mat Science and Engineering:C,2014,3(36):7-13.
[36] Lu K H,Chen Y W,Tsai P H,et al.Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells[J].Childs Nerv Syst,2009,25:543-550.
[37] Rashid A,Liu C,Sanli T,et al.Resveratrol enhances prostate cancer cell response to ionizing radiation.Modulation of the AMPK,Akt and m TOR pathways[J].Radiat Oncol,2011,6(1):144-155.
[38] Wang L,Long L M,Wang W J,et al.Resveratrol,a potential radiation sensitizer for glioma stem cells both in vitro and in vivo[J].J Pharmacol Sci,2015,129(4):216-225.
[39] Javvadi P,Segan A T,Tuttle S W,et al.The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased Reactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway[J].Mol Pharmacol,2008,73(5):1491-1501.
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