Effect of part of the trace elements on genomic stability
-
摘要: 维持基因组结构稳定性是生物生存的基础,微量元素作为人体生长发育所必需的营养成分,其摄入对于维持染色体和DNA结构的稳定具有重要的作用。本文介绍了锌、硒、铜、铁、铬等微量元素对基因组结构稳定性的影响,并就微量元素对基因组结构稳定性的影响机制作了介绍。Abstract: Maintaining genomic stability was the foundation of biological survival. As a kind of essential nutrients for human growth and development, trace elements play an important role in the maintenance of chromosome structure and DNA stability. The impacts of zinc, selenium, copper, iron and chromium on genomic stability were reviewed and the influence mechanism of trace elements on genomic stability were introduced in this article.
-
Keywords:
- trace elements /
- genomic stability /
- influence mechanism
-
[1] Ames B N.Micronutrients prevent cancer and delay aging[J].Toxicology Letters, 1998, 102:5-18.
[2] Fenech M.Chromosomal damage rate, aging, and dieta[J].Annals of the New York Academy of Sciences, 1998, 854 (1) :23-36.
[3] Nuttall J R, Oteiza P I.Zinc and the aging brain[J].Genes&Nutrition, 2014, 9 (1) :1-11.
[4] Sharif R, Thomas P, Zalewski P, et al.The role of zinc in genomic stability[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2012, 733 (1) :111-121.
[5] Ho E, Ames B N.Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line[J].Proceedings of the National Academy of Sciences, 2002, 99 (26) :16770-16775.
[6] 余晓丹.锌指蛋白结构和功能研究进展[J].国外医学卫生学分册, 2004, 31 (3) :171-175. [7] 赵楠, 赵飞, 李玉花.锌指蛋白结构及功能研究进展[J].生物技术通讯, 2009, 20 (1) :131-134. [8] Kunzmann A, Dedoussis G, Jajte J, et al.Effect of zinc on cellular poly (ADP-ribosyl) ation capacity[J].Experimental Gerontology, 2008, 43 (5) :409-414.
[9] Michelsen J W, Schmeichel K L, Beckerle M C, et al.The LIM motif defines a specific zinc-binding protein domain[J].Proceedings of the National Academy of Sciences, 1993, 90 (10) :4404-4408.
[10] Wallwork J C, Duerre J A.Effect of zinc deficiency on methionine metabolism, methylation reactions and protein synthesis in isolated perfused rat liver[J].The Journal of Nutrition, 1985, 115 (2) :252-262.
[11] Legrain Y, Touat-Hamici Z, Chavatte L.Interplay between selenium levels, selenoprotein expression, and replicative senescence in WI-38 human fibroblasts[J].Journal of Biological Chemistry, 2014 (289) :6299-6310.
[12] 熊咏民.硒蛋白及其基因多态性研究进展[J].国外医学:医学地理分册, 2010 (4) :211-215. [13] (美) J.曾普尔尼, (德) H.丹尼尔编著.分子营养学[M].罗绪刚等译.北京:科学出版社, 2008:182-183. [14] Philpott M, Lim C C, Ferguson L R.Dietary protection against free radicals:a case for multiple testing to establish structure-activity relationships for antioxidant potential of anthocyanic plant species[J].International Journal of Molecular Sciences, 2009, 10 (3) :1081-1103.
[15] Müller M, Banning A, Brigelius-FlohéR, et al.Nrf2 target genes are induced under marginal selenium-deficiency[J].Genes&Nutrition, 2010, 5 (4) :297-307.
[16] Ferguson L R, Karunasinghe N, Zhu S, et al.Selenium and its’role in the maintenance of genomic stability[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2012, 733 (1) :100-110.
[17] Arai Y, Ohgane J, Yagi S, et al.Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples[J].The Journal of Reproduction and Development, 2011, 57 (4) :507-517.
[18] Linder M C, Hazegh-Azam M.Copper biochemistry and molecular biology[J].The American Journal of Clinical Nutrition, 1996, 63 (5) :797S-811S.
[19] Li J, Quabius E S, Wendelaar Bonga S E, et al.Effects of water-borne copper on branchial chloride cells and Na-ATPase activities in Mozambique tilapia (Oreochromis mossambicus) [J].Aquatic Toxicology, 1998, 43 (1) :1-11.
[20] Manome H, Aiba S, Tagami H.Simple chemicals can induce maturation and apoptosis of dendritic cells[J].Immunology, 1999, 98 (4) :481-490.
[21] Mikulasova M, Szabova E, Melnik M.Antimutagenic effect of copper (II) complexes[J].Biologia-Bratislava-, 1998, 53:719-726.
[22] Linder M C.Copper and genomic stability in mammals[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001, 475 (1) :141-152.
[23] 杨天潼, 于晓军, 杨宏生.铁与营养免疫[J].免疫学杂志, 2004 (z1) :129-132. [24] Lee H S, Kim M S, Kim M H, et al.Iron status and its association with pregnancy outcome in Korean pregnant women[J].European Journal of Clinical Nutrition, 2006, 60 (9) :1130-1135.
[25] PráD, Franke S I R, Henriques J A P, et al.Iron and genome stability:an update[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2012, 733 (1) :92-99.
[26] 王福俤.中国生物微量元素研究的现状与展望[J].生命科学, 2012, 24 (8) :713-730. [27] Gao X, Qian M, Campian J L, et al.Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload[J].Free Radical Biology and Medicine, 2010, 49 (3) :401-407.
[28] Trumbo P, Yates A A, Schlicker S, et al.Dietary reference intakes:vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc[J].Journal of the American Dietetic Association, 2001, 101 (3) :294-301.
[29] 梁奇峰.铬与人体健康[J].广东微量元素科学, 2006, 13 (2) :67-69. [30] Eastmond D A, Mac Gregor J T, Slesinski R S.Trivalent chromium:assessing the genotoxic risk of an essential trace element and widely used human and animal nutritional supplement[J].CRC Critical Reviews in Toxicology, 2008, 38 (3) :173-190.
[31] Stout M D, Nyska A, Collins B J, et al.Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2years[J].Food and Chemical Toxicology, 2009, 47 (4) :729-733.
[32] Quievryn G, Peterson E, Messer J, et al.Genotoxicity and mutagenicity of chromium (VI) /ascorbate-generated DNA adducts in human and bacterial cells[J].Biochemistry, 2003, 42 (4) :1062-1070.
[33] Reynolds M, Stoddard L, Bespalov I, et al.Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis:linkage to DNA breaks in G2 phase by mismatch repair[J].Nucleic Acids Research, 2007, 35 (2) :465-476.
[34] Hamra F K, Eber S L, Chin D T, et al.Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity[J].Proceedings of the National Academy of Sciences, 1997, 94 (6) :2705-2710.
[35] Bird A P.Cp G islands as gene markers in the vertebrate nucleus[J].Trends Genet, 1987 (3) :342-347.
[36] 邓大君.DNA甲基化和去甲基化的研究现状及思考[J].遗传HEREDITAS (Beijing) , 2014 (36) :1-11.
计量
- 文章访问数:
- HTML全文浏览量:
- PDF下载量:
下载:
