五味子果汁对四氯化碳致大鼠急性肝损伤的保护作用

刘长姣; 于徊萍; 孟宪梅; 张守勤

doi:10.13386/j.issn1002-0306.2014.18.071

五味子果汁对四氯化碳致大鼠急性肝损伤的保护作用

1. 吉林工商学院粮油食品深加工吉林省高校重点实验室
2. 吉林大学生物与农业工程学院

基金项目:

国家自然科学基金资助项目(30472135)；

详细信息

作者简介:
刘长姣 (1981-) , 女, 博士, 讲师, 研究方向:天然产物有效成分提取与分离。;

中图分类号: R285.5;R285
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出版历程
- 收稿日期: 2013-12-26

Hepatoprotective effects of Schisandra chinesis (Turcz.) Bail juice on carbon tetrachloride induced acute liver damage in rats

Jilin Province Key Laboratory of Grain and Oil Processing, Jilin Business and Technology College
Biological and Agricultural College, Jilin University

摘要

摘要: 应用四氯化碳（CCl4）致大鼠急性肝损伤模型研究五味子果汁的护肝作用。实验各组大鼠灌胃相应实验样品,用生物化学法检测大鼠血清中丙氨酸氨基转移酶（ALT）、天门冬氨酸转氨酶（AST）和碱性磷酸酶（AKP）活性,肝匀浆中谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性及丙二醛（MDA）的含量,并观察肝组织光镜下病理变化。结果表明五味子果汁可以显著降低CCl4致急性肝损伤大鼠血清中AST和AKP的活性,增强大鼠肝组织匀浆中GHS-Px、SOD和CAT活力,显著降低MDA含量,与模型组相比各果汁组肝脏病理变化显著改善。证明五味子果汁对CCl4致大鼠急性肝损伤具有保护作用,为五味子果汁在保健食品中的应用提供依据。
- 五味子 /
- 护肝作用 /
- 果汁 /
- 四氯化碳
Abstract: The protective effects of Schisandra chinensis (Turcz.) Bail juice against liver damage in carbon tetrachloride (CCl4) -induced acute hepatotoxicity in rats were studied. Wista rats were orally fed with detected samples. The activities of ALT, AST and AKP in serum and GSH-Px, SOD and CAT in live were detected. The content of MDA in liver was also tested. The liver tissue pathological change was observed. The results showed that S. chinensis juice could significantly decrease the activities of AST and AKP in serum and significantly increase the activities of GSH-Px, SOD and CAT in liver. The content of MDA in liver was also significantly decreased. Compared with the model group the pathological change in liver of each S. chinensis juice group was significantly improved. The results proved that S. chinensis fruit juice had a protective effect on CCl4-induced acute liver damage in rats. This provided the basis for S. chinensis juice application in health food.
- Schisandra chinensis (Turcz.) Bail /
- liver protection /
- juice /
- carbon tetrachloride

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参考文献(9)

[1]	吴百灵.中药复方对四氯化碳致大鼠急性肝损伤保护作用的研究[D].沈阳:辽宁中医学院, 2002.
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文章访问数: 186
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五味子果汁对四氯化碳致大鼠急性肝损伤的保护作用

作者简介: 刘长姣 (1981-) , 女, 博士, 讲师, 研究方向:天然产物有效成分提取与分离。;

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出版历程

Hepatoprotective effects of Schisandra chinesis (Turcz.) Bail juice on carbon tetrachloride induced acute liver damage in rats

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出版历程

目录

作者简介:
刘长姣 (1981-) , 女, 博士, 讲师, 研究方向:天然产物有效成分提取与分离。;