鼠李糖乳酸杆菌对高脂饮食和链脲霉素诱发的Ⅱ型糖尿病小鼠的降糖作用

陈佩; 党辉; 张秋香; 刘小鸣; 赵建新; 陈永泉; 张灏; 陈卫

doi:10.13386/j.issn1002-0306.2013.24.021

鼠李糖乳酸杆菌对高脂饮食和链脲霉素诱发的Ⅱ型糖尿病小鼠的降糖作用

1. 江南大学食品科学与技术国家重点实验室
2. 陕西师范大学食品工程与营养科学学院
3. 江南大学食品学院

基金项目:

“十二五”国家863计划2011AA100901； “十二五”国家科技支撑计划(2013BAD18B01)；

详细信息

作者简介:
陈佩 (1983-) , 女, 博士研究生, 研究方向:食品生物技术。;

中图分类号: R587.1
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- 收稿日期: 2013-06-04

Antidiabetic effect of Lactobacillus rhamnosus in high-fat-fed and streptozotocin-induced type Ⅱ diabetic mice

State Key Laboratory of Food Science and Technology, Jiangnan University
College of Food Engineering and Nutritional Science, Shaanxi Normal University
School of Food Science and Technology, Jiangnan University

摘要

摘要: 主要研究了鼠李糖乳酸杆菌对Ⅱ型糖尿病小鼠的降糖作用。通过给小鼠连续12周喂食鼠李糖乳酸杆菌109CFU/d,结果表明,鼠李糖乳酸杆菌可减缓糖尿病小鼠体重下降,显著（p<0.05）降低空腹血糖和餐后2h血糖,提高机体对葡萄糖的耐受性,缓解胰岛素抵抗;显著（p<0.05）降低糖尿病小鼠的糖基化血红蛋白、内毒素、肿瘤坏死因子-α、白介素-6和丙二醛（MDA）含量,并显著（p<0.05）提高胰岛素、白介素-10、谷胱甘肽过氧化物酶（GSH-Px）、谷胱甘肽（GSH）和超氧化物歧化酶（SOD）的水平。胰腺组织切片染色发现,与模型组相比,鼠李糖乳酸杆菌可保护胰岛细胞免受损伤。因此,鼠李糖乳酸杆菌对糖尿病小鼠的胰岛具有保护作用,并可通过免疫调节和增强机体抗氧化能力降低糖尿病小鼠的血糖和减轻相关症状。
- 鼠李糖乳酸杆菌 /
- Ⅱ型糖尿病 /
- 血糖 /
- 吡格列酮
Abstract: To investigate the antidiabetic effect of Lactobacillus rhamnosus on type Ⅱ diabetic mice.L.rhamnosus was administered to mice with dose of 109CFU/d for 12 weeks.Results showed that L.rhamnosus could slow down weight loss in mice with diabetes and significantly decrease fasting and postprandial 2h blood glucose, and then significantly (p<0.05) improved the glucose tolerance to alleviate insulin resistance.L.rhamnosus significantly (p<0.05) reduced glycosylated hemoglobin, endotoxin, tumor necrosis factor-alpha, interleukin-6 and malondialdehyde compared with the control group.Values of insulin, interleukin-10, glutathione peroxides, glutathione, and superoxide dismutase were increased significantly ( p < 0.05) .Islets of Langerhans in the L.rhamnosus group were significantly protected from destruction compared with those in the control group.Studies had shown that L.rhamnosus could reduce the blood glucose and alleviate symptoms due to protect islets of Langerhans to be destroyed and improve the immunoregulatory properties and oxidative stress in type Ⅱ diabetic mice.
- Lactobacillus rhamnosus /
- type Ⅱ diabetic /
- blood glucose /
- pioglitazone

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参考文献(18)

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鼠李糖乳酸杆菌对高脂饮食和链脲霉素诱发的Ⅱ型糖尿病小鼠的降糖作用

作者简介: 陈佩 (1983-) , 女, 博士研究生, 研究方向:食品生物技术。;

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出版历程

Antidiabetic effect of Lactobacillus rhamnosus in high-fat-fed and streptozotocin-induced type Ⅱ diabetic mice

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出版历程

目录

作者简介:
陈佩 (1983-) , 女, 博士研究生, 研究方向:食品生物技术。;