马铃薯糖苷生物碱抗真菌活性构效关系研究
详细信息Structure-antifungal activity relationships of potato glycoalkaloids
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摘要: 采用平板菌丝生长抑制法测定了马铃薯糖苷生物碱茄碱和查茄碱、其酸水解产物β1-查茄碱、β2-查茄碱、γ-查茄碱和β2-茄碱及其硫酸化产物6-O-硫酸查茄碱和6-O-双硫酸茄碱的抗真菌活性,分析了糖链组成和结构与其活性的关系。结果表明,糖链的单糖组成、连接方式、连接顺序和单糖数目等对化合物的生物活性均有重要影响。Abstract: Potato glycoalkaloids α-chaconine and α-solanine, the acid-hydrolysis products β1-chaconine, β2-chaconine, γ-chaconine and β2-solanine, and the 6-O-sulfated products 6-O-sulfated chaconine and 6-O-disulfated solanine was examined for their percent inhibition on radial growth of fungi using an agar dilution method, and then, the structure-antifungal activity relationships of them was analyzed. Results indicated that the nature, order and number of attachment of the carbohydrate residues of potato glycoalkaloids could strongly influence the antifungal activity.
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